Symbol
Name
ID

Wls
wntless WNT ligand secretion mediator
MGI:1915401

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes

Microcephaly

Spastic gait

Dilated fourth ventricle

Hypoplasia of the corpus callosum

Cerebellar vermis hypoplasia

Intraventricular arachnoid cyst

Delayed speech and language development

Delayed early-childhood social milestone development

Intellectual disability

Hyperreflexia

Unsteady gait

Developmental regression

Delayed fine motor development

Delayed gross motor development

Seizure

Disease(s) Associated with WLS

Zaki syndrome

Mouse Phenotypes

abnormal neuron differentiation

abnormal neural tube morphology

abnormal neural tube closure

abnormal brain morphology

abnormal hindbrain development

abnormal midbrain development

abnormal midbrain-hindbrain boundary development

absent midbrain-hindbrain boundary

decreased forebrain size

decreased brain size

absent choroid plexus

absent tectum

absent tegmentum

absent midbrain

abnormal dentate gyrus morphology

abnormal metencephalon morphology

absent cerebellum

abnormal nervous system development

decreased neuron number

abnormal cranial nerve morphology

Availability

Mouse Genotype

Wls^em1Jgg/Wls^em1Jgg

Wls^em2Jgg/Wls^em2Jgg

Wls^tm1.1Lan/Wls^tm1.1Lan
H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ (conditional)

Wls^tm1.1Whsu/Wls^tm1.1Whsu
H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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